Investigating cases of central-line associated bloodstream infections including PICC lines and midlines. Neonatal sepsis is a major cause of morbidity and mortality. It is the third leading cause of neonatal mortality globally, constituting 13% of overall neonatal. In high-income countries, the mortality rate due to neonatal sepsis ranges from 5% to 20%, and neonatal [...]

Polyurethane and silicone PICC lines are defective products because there are safer materials that reduce the risk of hospital acquired bloodstream infections. In the United States, 250,000 hospital-acquired blood stream infections per year have been reported - 23,000 of them have been related to central venous catheter infection in 2009. Another study conducted in [...]

Adults and children with Short Bowel Syndrome are at serious risk of central line associate blood-stream infections and recurrent loss of venous access. Management of vascular access needs to be part of a comprehensive and multidisciplinary strategy aiming, as a first step, to preserve the vascular real estate of children requiring long-term PN.” …Dr. [...]

Acinetobacter infections in at-risk patients, emphasizing challenges and advocating for safer catheter materials to prevent severe complications Bloodstream infections from Acinetobacter baumannii-Acinetobacter calcoaceticus are more common in critically ill and debilitated institutionalized patients, who are heavily exposed to health care settings and invasive devices … (and) in hospital mortality rate was significantly higher among [...]

VRE bloodstream infections from infected central-line infections can cause long-term complications if not treated. Seven out of eleven CLA-BSIs (central-line associated bloodstream infections) in 2010 were caused by VRE (vancomycin resistant enterococcus) faecium” …Dr. Matthew Exline, MD, in Critical Care 2013, 17(R41). What else did Dr. Exline report in his article “Beyond the bundle-journey-journey [...]

Flaws in polyurethane catheters and the battle against central line infections We found no evidence of benefit or harm associated with miconazole and rifampin-impregnated PICCs compared with standard PICCs for newborn babies. Future research … should focus on other types of antimicrobial impregnation of PICCs and alternative approaches for preventing infection” … Professor Ruth Gilbert, MD, [...]

Central venous line bloodstream infections can lead to brain damage, bedsores, kidney failure, amputations, and death The fibrin sheath causes a confined space that surrounds the distal time of the PICC line, which restricted the flow of the injected contrast.” … Dr. Brent Burbridge. Canadian Association of Radiologist Journal 63 (2012) 323-328. What else [...]

Care bundles alone do not significantly reduce CLABSI rates; outdated materials like polyurethane and silicone may foster infections, despite compliance Improved compliance to central line care bundles alone may not be strong enough to significantly reduce central line-associated bloodstream infections (CLABSI) rates and the other factors unrelated to bundle compliance may have also influenced [...]

Sepsis impact on cerebral palsy risk in neonates and advocating for safer medical practices In babies with normal cranial ultrasounds, sepsis quadrupled the risk of cerebral palsy” … Janet Rennie, MD, Neonatologist, London, UK. Greg Vigna, MD, JD, national pharmaceutical injury attorney explains, “Infants born weighing less than 1500 grams are extremely vulnerable for [...]

Study finds over 75% of PICC line and central line infections come from the ICU Hospital-acquired bloodstream infections in ICU patients was mainly caused by Gram-negative bacteria … (and) was associated with 37.1% mortality, and by day-28 only 16.1% of the patients had been discharged alive from the hospital” … Alexis Tabah, MD, Brisbane, [...]