“Depo-Provera causes a 5.6x risk of brain tumors called meningiomas. Due to their location and/or size, meningiomas may cause serious disability. Meningiomas sometimes grow aggressively into key neurological structures, leading to hemiparesis, hydrocephalus, seizures, and cognitive impairment.”
~ Greg Vigna, MD, JD, national malpractice, product liability attorney, and brain injury physician (retired)
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Who is the Vigna Law Group?
“We represent women who have received four or more injections of Depo-Provera who developed a meningioma (a type of brain tumor).”
Greg Vigna, MD, JD
The Vigna Law Group is a national neurological injury law firm with unique experience in national pharmaceutical litigation. Greg Vigna, MD, JD, a retired brain injury physician, with co-counsel Ben Martin Law Group, have been jointly litigating pharmaceutical injuries involving mid-urethral slings, IVC filters, and hernia mesh for over a decade.
The Vigna Law Group Represents the Most Injured
What is Depo-Provera?
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A birth control medicine (medroxyprogesterone acetate) that is injected every three months
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74 million users worldwide
Who manufactures Depo-Provera?
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Pfizer
What has Pfizer known?
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Since the 1980s, it has been known that meningiomas contain progesterone receptors and Depo-Provera binds to meningioma progesterone receptors
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Since the 1950s, it has been known that meningiomas could have hormone dependent growth
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Since the year 2000, meningiomas progesterone receptors have been associated with a benign meningioma more so than the less favorable aggressive meningioma
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Since the year 2007, meningiomas progesterone receptors are less associated with recurrence after resection
What is known now?
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Prolonged use of Depo-Provera is associated with an excess risk of intracranial meningioma[1]
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Prolonged use of Depo-Provera is associated with a 5.6-fold risk compared to those not exposed to the medicine
[1] Roland, et al. Use of progestogens and the risk of intracranial meningioma: national case-control study. BMI 2024.
Learn more from our experts:
Depo-Provera and Meningiomas: The Epidemiology
“Now that it is known that Depo-Provera is associated with meningiomas and causes a 5.6x risk of this brain tumor, it is important to understand the baseline risks and epidemiology of meningiomas," states Greg Vigna, [...]