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“This shift in mutational landscape indicates the vulnerability of certain meningeal cells and mutations to hormone-induced tumorigenesis,” states M. Peyre, Neurosurgeon. Greg Vigna, MD, JD, national pharmaceutical injury attorney, states, “This study is pointing toward direct evidence that Depo-Provera causes mutations. The DNA footprint of meningiomas in women exposed to Depo-Provera is different when compared [...]
“More evidence is mounting on the association between the use of CPA (cyproterone acetate) and the development of meningiomas. The European Medicines Agency has recently issued restrictions regarding the use of CPA in doses exceeding 10 mg/day because of meningioma risk,” states Dr. Mirella Hage, endocrinologist. Greg Vigna, MD, JD, national pharmaceutical injury attorney, states, [...]
“Progesterone blood levels increase throughout pregnancy, peaking during the last 4 weeks of gestation and decreasing after labor and placental delivery," states Mariana A. Costa, Ph.D, pharmacology. Read Dr. Costa’s article: https://www.rbmojournal.com/article/S1472-6483(15)00495-2/fulltext Dr. Greg Vigna, MD, JD, national neurological injury attorney, and product liability attorney, states, “For decades, pregnancy has been associated with meningioma growth [...]
“These findings indicate that for patients with benign meningioma desiring to avoid the high stroke risk of fractionated proton-photon RT (radiotherapy), SRS (single-fraction stereotactic radiosurgery (SRS) has a comparable stroke risk profile to observation," states Dr. Jeremy N. Ciporen, Department of Neurological Surgery, Oregon Health and Science University. Greg Vigna, MD, JD, national pharmaceutical injury [...]
“High progesterone receptor positivity was linked to low grade tumors. Meningioma grade and many subtypes can be identified with the use of progesterone receptor expression, particularly in cases that are borderline,” states Dr. Assad Albayati. Greg Vigna, MD, JD, national pharmaceutical injury attorney, states, “In this study, like others, 79.3 % of Grade I meningiomas, [...]
“My law firm’s focus is the representation of women who used Depo-Provera and have required brain surgery for meningiomas that are progesterone receptor expression positive," states Greg Vigna, MD, JD, Board Certified PM&R. Greg Vigna, MD, JD, national pharmaceutical injury attorney, states, “Recent population studies from Europe describe a 5.5x risk of developing meningiomas in [...]
“Unfortunately, biological aggressiveness … can only be investigated after surgery. Differentiation between low- and high-grade meningiomas using conventional MRI is difficult. Imaging techniques that enable noninvasive, preoperative assessment of tumor biology and WHO grade could potentially be helpful in surgical planning," states Dr. K. Mariam Slot, Neurosurgeon, Amsterdam University Medical Centers. What did Dr. K [...]
“Incidental diagnosis of a meningioma is an injury in the 50% that are managed with active monitoring because the need for periodic diagnostic imaging, medical surveillance, and reasonable uncertainty as to the future is an injury,” states Dr. Greg Vigna, national neurological injury attorney and Board Certified Physical Medicine and Rehabilitation physician. What did Dr. Abdurrahman [...]
“Now that it is known that Depo-Provera is associated with meningiomas and causes a 5.6x risk of this brain tumor, it is important to understand the baseline risks and epidemiology of meningiomas," states Greg Vigna, MD, JD, national pharmaceutical injury attorney, PM&R MD. Dr. Greg Vigna, national pharmaceutical injury attorney, and retired Physical Medicine Rehabilitation [...]